ABSTRACT
Objective: the present study was conducted to study files of pediatric mesangioproliferative glomerulonephritis [MesPGN] cases attending Alexandria university children's hospital [AUCH] nephrology clinic during the period from [2001-2012] to identify their clinical presentations, course, complications, management and outcome
Methods: this was a retrospective study of children with MesPGN over the mentioned period. It included 37 patients. Data were collected from the files of all children diagnosed as having MesPGN and included personal characteristics, initial clinical presentation, investigations, renal biopsy reports, complications and treatment
Results: the mean age of disease onset in the studied cases was 4.51 years +/- 3.16. There was no significant difference in gender distribution. The most common presentation of primary MesPGN was nephrotic syndrome, while the secondary MesPGN mainly presented with lupus nephritis. Almost all patients had proteinuria. Hematuria was present in nearly half of the patients. Immunofluorescence studies were done only for 17 renal biopsies, 10 of them revealed deposits for immunoglobulins and 32.4% underwent remission while 10.8% died. Different treatment modalities were used according to the presentation
Conclusion: MesPGN is a heterogeneous disease with a wide range of presentations and its outcome varies accordingly, so it can't be considered a special entity like FSGS